Mometasone furoate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

糠酸莫米松是一种糖皮质激素，局部用于减少皮肤或呼吸道炎症。

Mometasone furoate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways. Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma for patients unresponsive to less potent corticosteroids, and penile phimosis. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.(In Vitro):Mometasone furoate binds to a glucocorticoid receptor causes conformational changes in the receptor, separation from chaperones, and the receptor moves to the nucleus.Mometasone furoate (0.1-10 μM; 2h before LPS stimulation) strongly inhibits LPS-stimulated nitrite production in a concentration-dependent manner in J774 macrophages, The IC50 value is 0.00024 μM for Mometasone?furoate in J774 cells.Mometasone furoate (0.1-10 μM; 2h before LPS stimulation) is more potent than DEX, it significantly inhibits iNOS expression at a 0.01 μM concentration whereas Dex became active at 0.1 μM. Additionally, the inhibition of cox-2 protein expression at 0.01 μM is 79% for Mometasone?furoate and 39% for Dex.

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SCH 32088

Endocrinology/Hormones

GR

Glucocorticoid Receptor

Inflammation/Immunology

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83919-23-7

521.43

C27H30Cl2O6

>98% (HPLC)

DMSO: 6 mg/mL (11.5 mM)

O=C(C1=CC=CO1)O[C@]2(C(CCl)=O)[C@H](C)C[C@@]3([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4(Cl)[C@@H](O)C[C@]23C)=O

(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate

(-20℃)

With Ice Pack

≥ 2 years